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Steroid‐hormone receptors in nonpalpable and more advanced stages of breast cancer. A contribution to the biology and natural history of carcinoma of the female breast
Author(s) -
Tinnemans J. G. M.,
Beex L. V. A. M.,
Wobbes Th.,
Sluis R. F.,
Raemaekers J. M. M.,
Benraad Th.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900915)66:6<1165::aid-cncr2820660615>3.0.co;2-u
Subject(s) - breast cancer , medicine , hormone receptor , hormone , cancer , oncology , steroid hormone , receptor , mammary gland , steroid , breast carcinoma , progesterone receptor , gynecology , endocrinology , estrogen receptor
Tumors of five groups of patients, with (1) nonpalpable primary breast cancer, (2) palpable operable primary breast cancer, (3) loco‐regionally advanced primary breast cancer, (4) first and (5) late metastatic breast cancer, were studied in respect to their steroid receptor content. A statistically significant decrease of progesterone receptor positive tumors and of tumors positive for estradiol and progesterone receptors, was found with increasing advance of the disease. A reversed extrapolation of these figures supports the hypothesis that every breast cancer contains steroid receptors and is hormone‐dependent from its inception.