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An evaluation of the prognostic significance of HLA‐DR expression in gastric carcinoma
Author(s) -
Hilton David A.,
West Kevin P.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900915)66:6<1154::aid-cncr2820660613>3.0.co;2-3
Subject(s) - medicine , lymph node , gastrectomy , staining , pathology , carcinoma , gastric carcinoma , clinical significance , lymph , immunohistochemistry , multivariate analysis , cancer , oncology
The prognostic value of histochemical staining for HLA‐DR was assessed retrospectively in 52 “curative” gastrectomy specimens from patients with gastric carcinoma. In addition other tumor variables, including histologic type, degree of differentiation, extent of local spread, prominence of mononuclear infiltrate, tumor edge, and lymph‐node metastases, were examined. Sixty‐five percent of the tumors showed positive staining for HLA‐DR, and these tumors had a higher mean and median survival at 5 years compared with negative tumors. However, on multivariate analysis the difference was not statistically significant. The authors conclude that, although HLA‐DR staining is associated with tumors of better prognosis, it cannot be used as an independent prognostic factor. Of the other tumor variables, only lymph‐node status was of prognostic significance.