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Papillary serous carcinoma of the peritoneum. A review of 33 cases treated with platin‐based chemotherapy
Author(s) -
Ransom David T.,
Patel Shreyaskumar R.,
Keeney Gary L.,
Malkasian George D.,
Edmonson John H.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900915)66:6<1091::aid-cncr2820660602>3.0.co;2-f
Subject(s) - medicine , debulking , laparotomy , surgery , peritoneum , chemotherapy , serous fluid , abdominal cavity , carcinoma , ovarian cancer , cancer
Thirty‐three patients were identified who had papillary serous carcinoma of the peritoneum (PSCP). The gross operative specimens, histopathologic condition, and treatment records were reviewed. The median age at presentation was 60 years (age range, 22 to 78 years). Abdominal pain and distention were the most common presenting symptoms. All patients had a total abdominal hysterectomy and bilateral salpingo‐oophorectomy, and all but two had debulking surgery. All patients had disease involving the omentum, the abdominal and pelvic peritoneum, and the surface of the ovaries, but none had intrinsic disease of the ovaries. Eight patients had disease outside of the abdominal cavity. Seven of these patients had malignant pleural effusions. All patients received platin‐based chemotherapy. Sixteen patients underwent second‐look laparotomy, two had no evidence of disease, and one had microscopic disease only. The median survival time for all patients was 17 months. Three patients are alive 6 to 7 years after the initial diagnosis. In conclusion, longterm survival can be achieved in some PSCP patients by debulking surgery and platin‐based chemotherapy.