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Carcinosarcoma of the gallbladder. A case report with immunohistochemical and ultrastructural studies
Author(s) -
Ishihara Tokuhiro,
Kawano Hiroo,
Takahashi Mutsuo,
Yokota Tadaaki,
Uchino Fumiya,
Matsumoto Noboru,
Fukuyama Norio
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900901)66:5<992::aid-cncr2820660532>3.0.co;2-2
Subject(s) - pathology , immunohistochemistry , carcinosarcoma , mesenchymal stem cell , rhabdomyosarcoma , gallbladder , ultrastructure , medicine , carcinoma , sarcoma
The authors present the histologic features, immunohistochemical findings, and ultrastructure of a carcinosarcoma of the gallbladder containing rhabdomyosarcoma as a mesenchymal element. A pedunculated polypoid tumor protruded into the lumen from the fundus of the gallbladder. The neoplasm contained two divergent components. One was malignant mesenchymal tissue with rhabdomyoblastic differentiation; the other was ordinary adenocarcinoma which was observed predominantly at the base of the polyp. Immunohistochemically, the cytoplasm of the rhabdomyoblasts stained with anti‐myoglobin, myosin, and muscle actin antibodies. Ultrastructurally, there were a large number of malignant mesenchymal tissues in which various stages of differentiated rhabdomyoblasts were noted. Ultrastructural study was particularly valuable for the identification of sarcomatous elements.