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Expression of the multidrug transporter, P‐glycoprotein, in acute leukemia cells and correlation to clinical drug resistance
Author(s) -
Kuwazuru Yasuo,
Yoshimura Akihiko,
Hanada Shuichi,
Utsunomiya Atae,
Makino Torahiko,
Ishibashi Kazuaki,
Kodama Masahiko,
Iwahashi Masato,
Arima Terukatsu,
Akiyama ShinIchi
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900901)66:5<868::aid-cncr2820660510>3.0.co;2-z
Subject(s) - medicine , p glycoprotein , chemotherapy , acute leukemia , multiple drug resistance , leukemia , drug resistance , myelodysplastic syndromes , oncology , immunology , drug , cancer research , pharmacology , bone marrow , biology , microbiology and biotechnology
The overexpression of a cell‐surface glycoprotein termed P‐glycoprotein (P‐gp) is frequently associated with multi‐drug resistance (MDR) in cell lines in vitro. To evaluate the implications of P‐gp expression in clinical drug resistance, the authors examined the expression of P‐gp in leukemia cells from patients with acute myelogenous leukemia (AML) and those with acute lymphoblastic leukemia (ALL) at initial presentation and relapse, using immunoblotting with a monoclonal antibody against P‐gp, C219. Nine of 17 patients with AML and four of 11 patients with ALL had P‐gp‐positive results at the initial presentation, and most P‐gp‐positive patients did not respond to chemotherapy. Four of seven patients at the relapsed stage and all three patients with preceding myelodysplastic syndrome had P‐gp‐positive results. The expression of P‐gp and clinical refractoriness to chemotherapy were highly correlated. These data indicate that the expression of P‐gp is closely related to clinical drug resistance in acute leukemia.