Premium
Clinically isolated mandibular relapse in childhood acute leukemia
Author(s) -
Rush Marjorie,
Toth Béla B.,
Pinkel Donald
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900715)66:2<369::aid-cncr2820660228>3.0.co;2-z
Subject(s) - medicine , radiation therapy , leukemia , complete remission , chemotherapy , childhood leukemia , acute leukemia , acute lymphocytic leukemia , surgery , pediatrics , oncology , lymphoblastic leukemia
With improved methods for preventing extramedullary relapse in the leptomeninges and gonads, the problem of clinically isolated relapse at other sites has become more significant. The authors report here two children with acute leukemia who developed mandibular relapse while in complete hematologic remission. One had been off chemotherapy for acute lymphoid leukemia for 2.5 years. The other child is apparently the first patient with promyeloid morphologic features to experience relapse at this site. Both children are in second complete remission and off treatment after local radiation therapy and second courses of chemotherapy. Review of these two and five previously reported isolated mandibular relapses in childhood leukemia indicate that they are usually delayed until after cessation of therapy. Treatment with radiation and combination chemotherapy can result in long remission and possibly cure.