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Flow cytometric DNA ploidy analysis of squamous cell carcinoma of the oral cavity: Comparison with clinical staging and histologic grading
Author(s) -
Hemmer Joerg,
Kreidler Joachim
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900715)66:2<317::aid-cncr2820660220>3.0.co;2-x
Subject(s) - medicine , grading (engineering) , basal cell , oral cavity , pathology , oncology , radiology , biology , ecology , orthodontics
The clonal DNA content of tumor biopsy specimens of 110 patients with primary and untreated squamous cell carcinoma of the oral cavity was determined by flow cytometric study. The ploidy status was compared with tumor size and histologic grading. Thirty tumors (27.3%) were diploid; in 80 cases (72.7%) cell lines with abnormal DNA content were detected. The portion of aneuploid tumors increased with decreasing degree of histologic differentiation ( P < 0.001) from G1 (38.1%) to G2 (76.6%) and G3 (92.0%). Only one of 13 T1 carcinomas (7.6%) showed abnormal clonal DNA content, but 76.9% of T2 and 90.6% T3 tumors ( P < 0.001) did. The emergence of aneuploid clones obviously represents a marker of malignancy progression in oral carcinoma.