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Surgery only for the treatment of patients with stage I (Cassady) Wilms' tumor
Author(s) -
Larsen Eric,
PerezAtayde Antonio,
Green Daniel M.,
Retik Alan,
Clavell Luis A.,
Sallan Stephen E.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900715)66:2<264::aid-cncr2820660212>3.0.co;2-z
Subject(s) - medicine , wilms' tumor , stage (stratigraphy) , surgery , wilms tumour , general surgery , paleontology , biology
A prospective pilot study was undertaken to examine the outcome of patients with Stage I (Cassady) Wilms' tumor treated with nephrectomy only. Eight consecutive patients fulfilling the criteria for Stage I (Cassady) Wilms' tumor (age < 2 years with unilateral, nonmetastatic, favorable histopathologic type, and tumor weight < 550 g) underwent nephrectomy with no further therapy. All eight patients were alive and free of disease with a mean follow‐up period of 5 years. There was one tumor recurrence that involved a metachronously occurring bilateral tumor. Overall survival (100%) and event‐free survival (88%) were comparable with clinical trials in which patients received adjuvant therapy. Patients with Stage I (Cassady) Wilms' tumor can be successfully treated with nephrectomy alone, thereby eliminating the toxicity of adjuvant therapy.