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Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression
Author(s) -
Standen Graham R.,
Jasani Bharat,
Wagstaff Michael,
Wardrop Charles A. J.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900701)66:1<162::aid-cncr2820660129>3.0.co;2-z
Subject(s) - paraproteinemia , myeloid leukemia , medicine , multiple myeloma , plasma cell dyscrasia , chronic lymphocytic leukemia , chronic leukemia , immunoglobulin light chain , breakpoint cluster region , leukemia , immunology , cancer research , acute leukemia , antibody , receptor
Two patients with plasma cell dyscrasia and IgG λ paraproteinemia in association with the rare disorder, chronic neutrophilic leukemia (CNL), are described. Cytogenetic studies excluded Philadelphia + chronic myeloid leukemia and molecular analysis of the breakpoint cluster region (bcr) revealed no evidence of clonal gene rearrangement. Nine similar cases of coexistent CNL and paraproteinemia have been identified in the literature and attention is drawn to the disproportionate excess of λ light chain restriction in this subset of patients. Evidence supporting a clonal origin of CNL is considered and the nature of the relationship between the chronic myeloid expansion and the development of multiple myeloma is discussed.