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Epidermal growth factor receptor expression in 72 meningiomas
Author(s) -
Jones Nigel R.,
Rossi Marco L.,
Gregoriou Mary,
Hughes John T.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900701)66:1<152::aid-cncr2820660127>3.0.co;2-5
Subject(s) - monoclonal antibody , epidermal growth factor , antigen , antibody , immunohistochemistry , epidermal growth factor receptor , receptor , microbiology and biotechnology , medicine , pathology , biology , immunology
The expression of epidermal growth factor receptor (EGF‐R) was studied immunohistochemically in 72 meningiomas using two monoclonal antibodies with specificities to protein and carbohydrate components, respectively, of the external domain of the EGF‐R. One third of the tumors had cytoplasmic and membrane positivity with the protein‐specific antibody but in none were there positive tumor cells with the carbohydrate‐specific antibody which recognizes the blood group A antigen. There was no difference in EGF‐R expression between typical and aggressive meningiomas. No evidence was found to support previous reports of specific EGF‐R immunoreactivity in the vascular endothelial cells of meningiomas. The authors believe this discrepancy to be due to detection of normal blood group A antigen attached to endothelial cells in patients of blood group A or AB. This occurs because many monoclonal anti‐EGF‐R antibodies are specific for A antigen which is found on the EGF‐R of A431 cells but has not been reported on EGF‐R elsewhere.