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Analysis of prognostic factors in disseminated prostatic cancer. An update
Author(s) -
Mulders Peter F. A.,
Dijkman Gerhard A.,
Moral Pilar Fernandez Del,
Theeuwes Ad G. M.,
Debruyne Frans M. J.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900615)65:12<2758::aid-cncr2820651225>3.0.co;2-6
Subject(s) - medicine , prostatic acid phosphatase , oncology , prostate cancer , logistic regression , univariate analysis , cancer , multivariate analysis , prostate specific antigen , proportional hazards model , prostate
A statistical analysis of prognostic factors in 175 patients with hormonally treated disseminated prostatic cancer was done. The prognostic significance of performance status (PS), hemoglobin (Hb), alkaline phosphatase (Alk P), and testosterone was assessed with a univariate analysis. The authors did not find significant prognostic value in age, tumor size or grade, prostatic acid phosphatase, and prostate‐specific antigen in these patients. In a multivariate logistic model (Cox regression), PS, Hb, and Alk P were found useful for dividing patients into prognostic groups. The prognosis for high‐risk patients on standard hormonal treatment was very poor. The authors concluded that research on prognostic factors is useful and permits a division of patients into risk groups that makes choice of treatment more accurate. The use of new treatment combinations as a start treatment is appropriate for high‐risk patients with disseminated prostatic cancer.