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Prognostic factors for survival in Stage I epithelial ovarian carcinoma
Author(s) -
Sevelda Paul,
Vavra Norbert,
Schemper Michael,
Salzer Heinrich
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900515)65:10<2349::aid-cncr2820651031>3.0.co;2-#
Subject(s) - medicine , stage (stratigraphy) , carcinoma , oncology , epithelial ovarian carcinoma , ovarian carcinoma , gynecology , ovarian cancer , cancer , biology , paleontology
In a retrospective analysis prognostic factors were studied in 204 patients with primary Stage I epithelial ovarian carcinoma (borderline tumors were excluded) treated between 1975 and 1987. Only histologic grade ( P = 0.01) and kind of surgery (total abdominal hysterectomy, bilateral salpingo‐oophorectomy ± omentectomy versus unilateral salpingo‐oophorectomy, P = 0.02) were found to have a significant influence on survival prognosis (Cox model). All other factors (age, the International Federation of Gynecology and Obstetrics [FIGO] stage, integrity of the capsule, unilaterality versus bilaterality, and histology) were of no prognostic importance. Unilateral salpingo‐oophorectomy without any additional staging reduces five‐year survival probability (62% versus 84%). Therefore this kind of operation should be abandoned. Furthermore, histologic grade should be a stratification criterion in studies, which will be necessary for proving the value of adjuvant therapy in Stage I epithelial ovarian carcinoma.