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Reduced hematologic response to alpha‐interferon therapy in patients with hairy cell leukemia showing a peculiar immunologic phenotype
Author(s) -
Lauria F.,
Raspadori D.,
Foa R.,
Zinzani P. L.,
Buzzi M.,
Gugliotta L.,
Macchi S.,
Tura S.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900515)65:10<2233::aid-cncr2820651012>3.0.co;2-k
Subject(s) - hairy cell leukemia , medicine , immunology , alpha interferon , cd5 , antibody , phenotype , monoclonal antibody , leukemia , alpha (finance) , interferon alfa , hairy cell , chronic lymphocytic leukemia , interferon , biology , biochemistry , gene , construct validity , nursing , patient satisfaction
Abstract Alpha‐interferon (α‐IFN) treatment is highly effective in normalizing the clinical, hematologic, and immunologic parameters of patients with hairy cell leukemia (HCL). Complete remissions (CR), however, are rare, and a few patients do not respond adequately to α‐IFN. That the poor response to α‐IFN treatment could be related to a particular immunologic surface marker profile of the HC was investigated in this study. The results showed that most patients who do not respond adequately to α‐IFN HC have a peculiar immunologic phenotype with a positive response to the Leu1 (CD5) monoclonal antibody, usually absent on HC but characteristically expressed on B‐chronic lymphocytic leukemia cells. Of nine HCL patients with this phenotype, only three had partial remissions (PR) and six minor responses (MR) compared with the three CR, 16 PR, and three MR observed in the 22 Leu1 (CD5)‐negative patients. The authors postulate that a more extensive immunologic analysis of HCL patients at diagnosis may be predictive of the response to IFN treatment.