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Iron‐accumulating adenomatous hyperplastic nodule with malignant foci in the cirrhotic liver histopathologic, quantitative iron, and magnetic resonance imaging in vitro studies
Author(s) -
Terada Tadashi,
Kadoya Masumi,
Nakanuma Yasuni,
Matsui Osamu
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900501)65:9<1994::aid-cncr2820650919>3.0.co;2-b
Subject(s) - pathology , medicine , magnetic resonance imaging , nodule (geology) , hepatocellular carcinoma , radiology , cancer research , biology , paleontology
Five iron‐accumulating adenomatous hyperplastic nodules (AHN) in cirrhotic livers were examined histologically, by quantitation of tissue iron, and by magnetic resonance imaging (MRI) in vitro . Histologically, one AHN was benign, while the other four contained malignant hepatocellular foci. Iron staining and quantitation of tissue iron revealed that AHN were rich in iron, but the malignant hepatocellular foci and surrounding regenerative nodules were relatively poor in iron. The MRI showed that AHN were hypointense while malignant hepatocellular foci and surrounding regenerative nodules were isointense. Thus, malignant hepatocellular foci within AHN corresponded to iron‐poor isointense foci. These findings suggest that malignant hepatocellular foci arising in iron‐accumulating AHN are resistant to iron accumulation and that iron‐accumulating AHN can be recognized with MRI in vitro as hypointense and malignant foci as isointense.