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Gamma heavy chain disease associated with Hodgkin' disease. Clinical, pathologic, and immunologic features of one case
Author(s) -
Benedetto Giorgio Di,
Cataldi Angelo,
Verde Antimo,
Gloghini Annunziata,
Nicolò Guido,
Pistoia Vito
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900501)63:9<1804::aid-cncr2820630924>3.0.co;2-8
Subject(s) - medicine , pathology , disease , cd15 , immunoglobulin light chain , antibody , gamma globulin , immunopathology , immunoelectrophoresis , immunology , biology , stem cell , cd34 , genetics
This report describes the clinical, pathologic, and immunologic features of a patient with γ heavy chain disease (γ‐HCD) associated with Hodgkin' disease (HD). The diagnosis of γ‐HCD was established by serum electrophoresis and immunoelectrophoresis and confirmed by biochemical analysis of patient' serum showing the presence of an incomplete γ chain, with an approximate molecular weight of 40 kilodaltons. The diagnosis of HD rested upon the presence of systemic lymphadenopathy, the typical histologic pattern and reactivity of Reed‐Sternberg cells with the LeuM1‐CD15 monoclonal antibody. The two diseases developed independently, in the absence of any immunosuppressive treatment. Furthermore, there was some evidence suggesting that HD tissue was not responsible for the production of the incomplete γ chain. This and similar cases may provide a model for a better understanding of the events leading to the simultaneous outgrowth of two lymphoid neoplasias in the same patient.