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Inflammatory myofibrohistiocytic proliferation simulating sarcoma in children
Author(s) -
Tang Thomas T.,
Segura Annette D.,
Oechler Herbert W.,
Harb Joseph M.,
Adair Stuart E.,
Gregg David C.,
Camitta Bruce M.,
Franciosi Ralph A.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900401)65:7<1626::aid-cncr2820650729>3.0.co;2-v
Subject(s) - medicine , hypergammaglobulinemia , microcytic anemia , sarcoma , pathology , lesion , anemia , hypochromic anemia , immunology , disease
The term “inflammatory myofibrohistiocytic proliferation” (IMP) has been proposed to replace the conventional designations of plasma cell granuloma and inflammatory pseudotumor. Three cases of extrapulmonary IMP in children are reported, including an intracerebral lesion which has been formerly undescribed. In children, IMP may be associated with microcytic hypochromic anemia, hypergammaglobulinemia, and high erythrocyte sedimentation rate. In this clinical setting, differentiation of a rapidly growing but benign IMP from a bona fide sarcoma is of paramount importance.