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Somatostatin‐producing duodenal carcinoids in patients with von recklinghausen's neurofibromatosis. A predilection for black patients
Author(s) -
Burke Allen P.,
Sobin Leslie H.,
Shekitka Kris M.,
Federspiel Birgitte H.,
Helwig Elson B.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900401)65:7<1591::aid-cncr2820650723>3.0.co;2-n
Subject(s) - medicine , psammoma body , neurofibromatosis , duodenum , pathology , abdominal pain , gastroenterology , immunohistochemistry
Eight patients with von Recklinghausen's disease (VRD) and duodenal carcinoids are presented. Seven patients were black, and one white. Six of the eight were women. The presenting symptom was either jaundice or abdominal pain. All tumors were located in the second portion of the duodenum, and three were multiple. Associated tumors other than neurofibromas included multiple leiomyomas, meningioma, neurofibrosarcoma, and prostatic sarcoma. Seven tumors had psammoma bodies, and in three they were numerous. Somatostatin‐positive cells were demonstrated in all cases. Two tumors had spread to regional lymph nodes at the time of surgery. There appears to be a predilection for black patients among those with VRD and duodenal carcinoids.