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Studies on components of the contact phase system in patients with advanced gastrointestinal cancer
Author(s) -
Roeise Olav,
Sivertsen Steinar,
Ruud Tom Erik,
Bouma Bonno N.,
Stadaas Jan O.,
Aasen Ansgar O.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900315)65:6<1355::aid-cncr2820650618>3.0.co;2-1
Subject(s) - prekallikrein , medicine , high molecular weight kininogen , cancer , gastrointestinal cancer , gastrointestinal tract , gastroenterology , contact system , metastasis , colorectal cancer , intestinal cancer , kallikrein , kininogen , endocrinology , enzyme , bradykinin , biochemistry , receptor , chemistry , mechanical engineering , engineering
The authors have studied components of the contact system in plasma obtained from patients with advanced gastrointestinal cancer. Plasma samples from 118 healthy blood donors served as controls. Plasma prekallikrein (PKK) values, evaluated by chromogenic peptide substrate technique, were significantly decreased in patients with cancer compared with healthy blood donors. High molecular weight kininogen (HMwK) and Hageman factor (FXII) values, assayed by immunochemical techniques, were also decreased in the patients with cancer. The changes of contact factors were most pronounced in patients with liver metastasis. The most striking observation in our study, however, was the elevated inhibitor values in patients with cancer. Alpha‐2‐macroglobulin (α2M) and C1 inhibitor (C1INH) values, determined both by functional and immunochemical techniques, were markedly increased in patients with cancer. In conclusion, this study shows that patients with intestinal cancer have reduced values of contact factors and markedly elevated inhibitor values which indicate that development of malignant tumors in the gastrointestinal tract is associated with changes in the contact system of plasma.