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The unbalanced 1;7 translocation in de novo myelodysplastic syndrome and its clinical implication
Author(s) -
Horiike Shigeo,
Taniwaki Masafumi,
Misawa Shinichi,
Nishigaki Hikari,
Okuda Tsukasa,
Yokota Shohei,
Kashima Kei,
Inazawa Johji,
Abe Tatsuo
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900315)65:6<1350::aid-cncr2820650617>3.0.co;2-j
Subject(s) - cytopenia , chromosomal translocation , medicine , karyotype , bone marrow , hypergammaglobulinemia , myelodysplastic syndromes , pathology , peripheral blood , chromosome , cytogenetics , immunology , gastroenterology , disease , biology , genetics , gene
In our chromosome study of 97 patients with myelodysplastic syndrome (MDS), six showed an unbalanced translocation between chromosomes 1 and 7 [−7, +der(1)t(1;7)(p11;p11)]. All of them had morphologic myelodysplasia in trilineage of bone marrow cells, and cytopenia was the major finding in the peripheral blood. All six patients had symptoms of infection at the time of diagnosis, and five showed immunologic abnormalities (polyclonal hypergammaglobulinemia in four and increased marrow plasma cells in three). None of the patients survived more than 11 months after the diagnosis; the median survival time was 4 months. Both of the two patients whose karyotypes were reexamined in the course of their disease showed karyotypic evolution accompanying the coincidental leukemic transformation. Six patients with MDS who had the same chromosome abnormality [t(1;7)] are described and their characteristic clinical features are presented.