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Lymphomatoid granulomatosis in the acquired immunodeficiency syndrome. Evidence of Epstein‐Barr virus infection and B‐cell clonal selection without myc rearrangement
Author(s) -
Mittal Khushbakhat,
Neri Antonio,
Feiner Helen,
Schinella Roger,
Alfonso Flores
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900315)65:6<1345::aid-cncr2820650616>3.0.co;2-8
Subject(s) - lymphomatoid granulomatosis , virus , virology , medicine , viral disease , epstein–barr virus , immunodeficiency , immunopathology , immunology , gammaherpesvirinae , pathology , herpesviridae , lymphoma , immune system
A case of lymphomatoid granulomatosis of lung that occurred in a patient with the acquired immunodeficiency syndrome (AIDS) was studied by light microscope, electron microscope, cell surface markers, and Southern blot test. Clonal selection of two clones of B‐cells was seen. Two clones were infected with Epstein‐Barr virus. There was no c‐myc rearrangement. Lymphomatoid granulomatosis in patients with AIDS may represent multiclonal selection of B‐lymphocytes in association with Epstein‐Barr virus infection.