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Urinary neopterin excretion in patients with uterine sarcomas
Author(s) -
Fuith Lothar C.,
Hetzel Heinz,
Fuchs Dietmar,
Hausen Arno,
Reibnegger Gilbert,
Werner Ernst R.,
Wachter Helmut
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900301)65:5<1228::aid-cncr2820650532>3.0.co;2-v
Subject(s) - neopterin , medicine , urinary system , excretion , urine , cellular immunity , gastroenterology , pathology , immunology , immune system
Neopterin, a pyrazinopyrimidine compound, is a marker of activation of cell‐mediated immunity. Urinary neopterin concentrations were measured in a total of 44 patients with uterine sarcomas. Pretherapeutic neopterin excretions were elevated in 78% (14/18). The mean neopterin concentration of patients with sarcomas was significantly higher ( P < 0.0001) than that obtained in women with benign myomas and healthy controls. Furthermore, a significant correlation of normal or raised neopterin concentrations with the clinical course of disease was found. These data suggest that urinary neopterin measurement might be a useful immunologic marker for women with uterine sarcomas.