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Prognostic Value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary
Author(s) -
Klemi Pekka J.,
Joensuu Heikki,
Salmi Tuula
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900301)65:5<1189::aid-cncr2820650527>3.0.co;2-b
Subject(s) - flow cytometry , ovary , ploidy , nuclear dna , dna , cell , pathology , andrology , medicine , biology , oncology , microbiology and biotechnology , genetics , gene , mitochondrial dna
The nuclear DNA content and S‐phase fraction of 23 ovarian granulosa cell tumors were measured from paraffin‐embedded tissue with flow cytometry. Crude survival of the patients with a euploid tumor (17 diploid, one tetraploid) was more favorable than that of the patients with an aneuploid tumor (n = 5, P = 0.02). The percentage of S‐phase cells was a good predictor of survival. If more than 6% S‐phase cells were present in the DNA histogram, both crude survival ( P = 0.0001) and survival corrected for intercurrent deaths ( P = 0.0001) were clearly inferior as compared with tumors with less than 6% S‐phase cells. The results indicate that DNA flow cytometric study may provide a rapid and valuable method to predict the biological behavior of granulosa cell tumors of the ovary.