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Prognostic factors after hepatectomy for hepatocellular carcinomas. A univariate and multivariate analysis
Author(s) -
Yamanaka Naoki,
Okamoto Eizo,
Toyosaka Akihiro,
Mitunobu Masao,
Fujihara Shiro,
Kato Toshihiro,
Fujimoto Jiro,
Oriyama Tuyosi,
Furukawa Kazutaka,
Kawamura Eisuke
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900301)65:5<1104::aid-cncr2820650511>3.0.co;2-g
Subject(s) - medicine , hepatectomy , univariate analysis , indocyanine green , multivariate analysis , metastasis , surgical margin , hepatocellular carcinoma , univariate , resection margin , resection , proportional hazards model , surgery , radiology , oncology , multivariate statistics , cancer , statistics , mathematics
The current study determines the prognostic factors after hepatectomy for hepatocellular carcinomas. The 295 patients who underwent hepatectomy from 1973 through 1987 were included for a univariate and a Cox multivariate analysis. The favoring conditions were determined as follows. The essential requirements are (1) the absence of tumor thrombi; (2) no intrahepatic metastasis, but even when present, it should be close to the main tumor and removed with a massive resection; and (3) retention rate of indocyanine green dye (ICG) at 15 minutes should be within 14 ± 4.2% (M ± SD) to allow that resection. The desired requirement is that the tumor size should preferably be less than 5 cm; a wider free margin from tumors (⩾ 1 cm) is recommended, but not determining factor. The eligible patients, having no thrombi, no intrahepatic metastasis, a tumor size of 5 cm or less, negative surgical margin (⩾ 1 cm), had achieved a 5‐year survival of 78%. In conclusion, resection therapy is the first option for patients with those requirements.