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Encasement and other deformations of tumor‐embedded host arteries due to loss of medial smooth muscles. Morphometric and three‐dimensional reconstruction studies on some human carcinomas
Author(s) -
Yaegashi Hiroshi,
Takahashi Tohru
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900301)65:5<1097::aid-cncr2820650510>3.0.co;2-4
Subject(s) - medicine , autopsy , blood flow , anatomy , hemodynamics , cancer , vasoactive , carcinoma , blood vessel , artery , pathology , radiology
Surgical materials from 20 patients with gastric carcinoma and ten with colonic carcinoma, and autopsy materials from ten patients with pancreatic carcinoma were submitted to the morphometric study of host arteries remaining in and around the tumors, to analyze whether and to what degree the smooth muscles of their media were lost. An explanation would be made of the inertia of tumor‐supplying vessels based on their retarded response to vasoactive drugs. It was noted that as arteries advance from a distance toward the inside of a tumor, their media loses smooth muscles gradually, and become amuscular tubes incapable of blood flow regulation. This appears responsible for the abnormal hemodynamics of tumor tissues. Host arteries embedded in cancer were often deformed to aneurysmal or crumpled shapes; this, which also results from relaxation of atonic vessels, was considered to be the pathologic background for the unusual vascular images characteristic of cancer angiograms.