Premium
Effect of transcatheter arterial embolization on the boundary architecture of hepatocellular carcinoma
Author(s) -
Wakasa Kenichi,
Sakurai Masami,
Kuroda Chikazumi,
Marukawa Taro,
Monden Morito,
Okamura Jun,
Kurata Akihiko
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900215)65:4<913::aid-cncr2820650416>3.0.co;2-9
Subject(s) - medicine , arterial embolization , hepatocellular carcinoma , lipiodol , embolization , stromal cell , hyaline , granulation , capsule , radiology , pathology , physics , classical mechanics , botany , biology
Daughter nodules and intrahepatic metastases are resistant to conventional transcatheter arterial embolization therapy. To clarify the mechanism of this resistance, the boundaries of hepatocellular carcinomas and their relationship to the blood supply were studied. The boundaries of the hepatocellular carcinomas studied were classified as one of five types: encapsulated, granulation, stromal, replacing, or sinusoidal. The granulation and stromal types had a capsule‐like structure, but lacked the hyalinization which is the hallmark of a true tumor capsule. The granulation and stromal types could also be differentiated from the encapsulated types because of their different blood supplies and the differing effects of transcatheter arterial embolization. When barium sulfate was infused into the portal vein, it did not enter into encapsulated tumors, but it entered granulation and stromal type tumors. Small nodules such as daughter nodules and intrahepatic metastases do not have capsules, and so have a blood supply that makes them resistant to conventional transcatheter arterial ebolization therapy.