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Acute hepatic injury after the withdrawal of immunosuppressive chemotherapy in patients with hepatitis B
Author(s) -
Pinto Paul C.,
Hu Eddie,
BernsteinSinger Marjorie,
PinterBrown Lauren,
Govindarajan Sugantha
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900215)65:4<878::aid-cncr2820650409>3.0.co;2-k
Subject(s) - medicine , immunosuppression , chemotherapy , complication , corticosteroid , cytolysis , pathophysiology , gastroenterology , hepatitis , immunology , cytotoxicity , biochemistry , chemistry , in vitro
Five patients with lymphoproliferative malignancies and chronic hepatitis B suffered severe acute hepatic injury after the withdrawal of multiagent chemotherapy that included high‐dose corticosteroid. Four patients died of hepatic failure, three of whom received corticosteroid as treatment for the hepatic injury. We believe that the cause of this entity is massive immune‐associated cytolysis of hepatitis B virus infected hepatocytes occurring after a period of immunosuppression and increased viral replication. The literature regarding this complication of chemotherapy and its pathophysiology is reviewed.