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Kaposi's sarcoma in immunosuppression possibly the result of a dual viral infection
Author(s) -
Siegal Bruno,
LevintonKriss Sofia,
Schiffer Aaron,
Sayar Joshua,
Engelberg Isaac,
Vonsover Ami,
Ramon Yochanan,
Rubinstein Ethan
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900201)65:3<492::aid-cncr2820650320>3.0.co;2-c
Subject(s) - medicine , sarcoma , immunosuppression , cytomegalovirus , discontinuation , virus , kaposi's sarcoma , virology , immunology , viral disease , herpesviridae , pathology , human herpesvirus
Kaposi's sarcoma of the gingiva and skin developed in an HIV‐negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two types of virus‐like particles. CMV DNA was identifiable in the cell line whereas infectious CMV could be isolated only after repeated passages (only after 3 months of culture). The other virus could not be identified, but did not appear to be either HIV or papilloma virus. The patient's tumor regressed after the discontinuation of cyclosporine therapy and the recovery from the acute CMV infection.