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Intratumor administration of beta‐interferon in recurrent malignant gliomas. A phase I clinical and laboratory study
Author(s) -
Fetell Michael R.,
Housepian Edgar M.,
Oster Martin W.,
Cote Debra N.,
Sisti Michael B.,
Marcus Stephen G.,
Fisher Paul B.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900101)65:1<78::aid-cncr2820650117>3.0.co;2-5
Subject(s) - medicine , ommaya reservoir , chills , interferon , vomiting , nausea , glioma , interferon alfa , alpha interferon , chemotherapy , gastroenterology , bleomycin , toxicity , surgery , immunology , cancer research
We administered doses of 5 to 180 × 10 6 IU of beta‐serine‐interferon (IFN‐β ser 17 ) twice weekly to 20 patients with recurrent malignant gliomas in a Phase I study. Interferon was given through an Ommaya reservoir connected by a catheter to the tumor cavity. Side effects of interferon therapy occurred in only one patient and consisted of nausea, vomiting, fever, and chills after each treatment, presumably due to rapid diffusion of interferon into ventricular cerebrospinal fluid (CSF). Problems with the Ommaya reservoir (obstruction in two patients and infection in four patients) led to six patients being terminated from the study, and represent the major difficulty with this form of therapy. Although this was primarily a study of interferon toxicity, of 12 evaluable patients, 3 had stable disease for 148, 192, and 539 days; 9 had progressive disease. In addition, we tested the effect of IFN‐β ser 17 on the growth of early passage in vitro cultures of malignant gliomas established from patients. Growth inhibition varied from 0% to more than 50%. In all cultures evaluated, the combination of recombinant gamma‐interferon plus IFN‐β ser 17 enhanced growth inhibition. Further clinical and laboratory study is necessary to better define the therapeutic efficacy of IFN‐β ser 17 and the role of combinations of interferons in the treatment of malignant gliomas.