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Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma
Author(s) -
Sonneveld Pieter,
Abels Johannes,
Kurth Karl Heinz,
Hagemeyer Anne
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19900101)65:1<23::aid-cncr2820650107>3.0.co;2-q
Subject(s) - medicine , malignancy , chemotherapy , carcinoma , mitomycin c , refractory (planetary science) , cancer , leukemia , urinary bladder , neoplasm , bladder cancer , pathology , surgery , physics , astrobiology
Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C. In one patient, karyotypic abnormalities (−5, 7q‐) typical of a therapy induced malignancy were associated with rapid progression of a refractory anemia with excess blasts in transformation to an acute non‐lymphocytic leukemia. Intravesical chemotherapy may be associated with a risk of secondary malignancy.