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Possible disorder of B‐cell‐related surveillance and malignant lymphoma of the thyroid
Author(s) -
Matsubayashi Sunao,
Tamai Hajime,
Morita Tetsuya,
Matsuzuka Fumio,
Kuma Kanji,
Miyazaki Tokiko,
Matsumoto Hideo,
Nagataki Shigenobu,
Volpé Robert
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891201)64:11<2259::aid-cncr2820641113>3.0.co;2-0
Subject(s) - allotype , medicine , lymphoma , thyroid , antigen , pathogenesis , human leukocyte antigen , antibody , thyroid lymphoma , malignant lymphoma , immunology , b cell lymphoma , pathology , thyroid cancer , cancer research , thyroiditis
Malignant lymphoma of the thyroid has been shown to be of B‐cell origin. To clarify its genetic origin, we have investigated HLA‐A, B, C, and DR antigens, and the immunoglobulin G (IgG) heavy‐chain allotype, Gm, in such patients. There was no correlation between the occurrence of malignant lymphoma of the thyroid and the HLA antigens tested, but patients with this lymphoma had significantly lower frequency of the Gm 1,21 haplotype than healthy persons. These results suggested a disorder of surveillance related to B‐cells may be involved in the pathogenesis of malignant lymphoma of the thyroid.