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Paraneoplastic eosinophilia. Report of a case with in vitro studies of hemopoiesis
Author(s) -
Balducci Lodovico,
Chapman Stanley W.,
Little Diane D.,
Hardy Cheryl L.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891201)64:11<2250::aid-cncr2820641111>3.0.co;2-x
Subject(s) - eosinophilia , eosinophil , haematopoiesis , medicine , myeloid , in vitro , pathology , chemotherapy , medullary cavity , immunology , eosinophilic , cancer research , stem cell , biology , asthma , biochemistry , genetics
Eosinophilia is an unusual paraneoplastic manifestation. The authors describe for the first time the association of eosinophilia and metastatic medullary carcinoma of the thyroid. The eosinophil count normalized during remission after chemotherapy but increased at time of relapse. The patient's serum enhanced eosinophilic differentiation of human multipotential hemopoietic precursors but was inhibitory to in vitro growth of murine myelopoietic precursors. The number of multipotential colonies which could be cultured in vitro was lower in the patient's peripheral blood than in normal controls. The authors conclude that a tumor‐related circulating factor caused eosinophilia by inducing eosinophilic differentiation and inhibiting myeloid differentiation. Such a mechanism of paraneoplastic eosinophilia has not been previously described.