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Prognosis in childhood rhabdomyosarcoma of the extremity
Author(s) -
Ghavimi F.,
Mandell L. R.,
Heller G.,
Hajdu S. I.,
Exelby P.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891201)64:11<2233::aid-cncr2820641108>3.0.co;2-6
Subject(s) - medicine , rhabdomyosarcoma , stage (stratigraphy) , radiation therapy , multivariate analysis , univariate analysis , retrospective cohort study , surgery , chemotherapy , cancer , disease , alveolar rhabdomyosarcoma , survival rate , overall survival , survival analysis , oncology , sarcoma , pathology , paleontology , biology
From 1970 to 1987, 34 patients younger than 22 years of age with extremity rhabdomyosarcoma were treated at the Memorial Sloan‐Kettering Cancer Center (MSKCC). All patients were treated according to protocols consisting of surgery, radiotherapy, and multiple drug chemotherapy. Sixteen of 34 patients survived, and 14 continue to be disease‐free; the 5‐year survival rate was 44%. A retrospective univariate analysis of data according to the TNM staging system was undertaken. Tumor invasion, regional nodal in/olvement, distant metastases, and alveolar histologic condition each had a significant impact on survival. However, in multivariate analysis, the stage of disease at diagnosis was the most important predictor of survival outcome.