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Cisplatin, vinblastine, and bleomycin combination in the treatment of resistant high‐risk. Gestational trophoblastic tumors
Author(s) -
Azab Mohamed,
Droz JeanPierre,
Theodore Christine,
Wolff JeanPierre,
Amiel JeanLouis
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891101)64:9<1829::aid-cncr2820640912>3.0.co;2-g
Subject(s) - medicine , bleomycin , vinblastine , cisplatin , regimen , chemotherapy , surgery , combination chemotherapy , toxicity
Eight patients with high‐risk gestational trophoblastic tumors (GTT) resistant to multiagent chemotherapy were treated with the combination of cisplatin, vinblastine, and bleomycin (PVB). All patients had a metastatic disease including three patients with two metastatic sites and two patients with brain metastases. Four patients achieved complete remission (CR) with the PVB regimen (50%). Three additional patients had partial remission (PR) of whom two were converted into CR by surgery of resistant residual lesions. One patient relapsed and the remaining five patients in CR were cured (62%). A multimodal approach was necessary in most patients as five of them had hysterectomy and two patients had a whole‐brain irradiation. Toxicity was mild with no treatment related deaths.