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Effect of perioperative transfusions on survival in osteosarcoma treated by multimodal therapy
Author(s) -
Chesi Rina,
Cazzola A.,
Bacci G.,
Borghi B.,
Balladelli A.,
Urso G.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891015)64:8<1727::aid-cncr2820640829>3.0.co;2-y
Subject(s) - medicine , perioperative , osteosarcoma , overall survival , retrospective cohort study , transfusion therapy , surgery , oncology , blood transfusion , pathology
We report on a retrospective study of 155 patients amputated for nonmetastatic osteosarcoma of the long bones. Among the various prognostic variables considered, a significant correlation was found only between survival and transfusions. In this report, the authors consider some hypotheses reported by others for tumors of a different nature and site and conclude that perioperative transfusion may induce depression in the immune response, which is the cause of a shorter survival in the patients reviewed.