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Immunohistochemical assessment of splenic lymphocyte and macrophage subpopulations in patients with gastric cancer
Author(s) -
Falk Stephan,
Seipelt Gernot,
Müller Hartmut,
Stutte Hans Jochen
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891015)64:8<1646::aid-cncr2820640815>3.0.co;2-e
Subject(s) - mononuclear phagocyte system , medicine , pathology , immunohistochemistry , spleen , lymphatic system , immune system , cancer , macrophage , lymphocyte , phagocyte , peripheral blood mononuclear cell , lymph , immunology , biology , in vitro , biochemistry
In order to assess the effects of malignant tumors on the immune system, 25 spleens from patients with gastric carcinoma were studied by in situ immunohistochemical methods for lymphocyte subsets and cells of the mononuclear phagocyte system. Highly significant reductions of CD4+ T cells ( P < 0.001), Ki M2+ and Ki M‐3+ MPS cells ( P < 0.02 and P < 0.05), and a stage‐dependent reduction of Ki 67+ B cell proliferation activity ( P < 0.05) were seen in spleens of patients with gastric cancer. These results, which were obtained by morphologic methods in a noninvolved lymphatic organ, reflect the systemic immunosuppressive and immunodepleting effects of malignant tumors that are probably mediated by tumor‐associated cytokines.