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UCHL1‐positive extranodal lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract
Author(s) -
Nakamine Hirokazu,
Sakamoto Haruhiko,
Tanaka Tomoyuki,
Nakashima Nobukazu,
Takenaka Toru,
Maeda Jiro
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891001)64:7<1500::aid-cncr2820640723>3.0.co;2-o
Subject(s) - pathology , gastrointestinal tract , lymphoma , medicine , immunohistochemistry , alimentary tract , bone marrow , antigen , spleen , immunology
Abstract Histopathologic and immunohistochemical studies were done on paraffin sections from a patient with alimentary tract lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract (MLP). Diffuse, but not follicular, proliferation of medium‐sized lymphoid cells was noted in the polypoid lesions of the alimentary tract, peripancreatic lymph nodes, spleen, liver, and bone marrow. These cells possessed a T‐cell‐related antigen (UCHL1), but were negative for the B‐cell‐related and myeloid cell‐related antigens examined. Because neoplastic cells in MLP are usually of B‐cell origin, the current case will provide important information on the relation between phenotypes and morphologic patterns of proliferation.