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Relation between DNA ploidy and the clinical behavior of phyllodes tumors
Author(s) -
Layfield Lester J.,
Hart John,
Neuwirth Harry,
Bohman Roger,
Trumbull William E.,
Giuliano Armando E.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19891001)64:7<1486::aid-cncr2820640721>3.0.co;2-7
Subject(s) - pathology , phyllodes tumor , medicine , ploidy , giant cell , metastasis , lesion , flow cytometry , fibroadenoma , biology , cancer , immunology , breast cancer , genetics , gene
We studied the DNA histograms obtained by flow cytometry from a series of six giant fibroadenomas and ten phyllodes tumors to determine if the analysis of DNA ploidy would help to predict clinical behavior. We were unable to document any relation between ploidy and histologic appearance, recurrence, metastasis, lesion size, or patient age. DNA aneuploid stem cell lines were seen in 75% of histologically benign phyllodes tumors, 50% of histologically malignant phyllodes tumors, and approximately 33% of giant fibroadenomas.