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Lymphomatoid granulomatosis. A case for aggressive therapy
Author(s) -
Jenkins Terry R.,
Zaloznik Arlene J.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890915)64:6<1362::aid-cncr2820640631>3.0.co;2-p
Subject(s) - medicine , lymphomatoid granulomatosis , prednisone , vincristine , cyclophosphamide , methotrexate , bleomycin , vasculitis , chemotherapy , aggressive lymphoma , lymphoma , dermatology , disease , surgery , rituximab
Lymphomatoid granulomatosis is an uncommon disorder with features of vasculitis and lymphoma. Treatment has usually consisted of steroids and, occasionally, single cytotoxic drugs, but prognosis remains poor. The authors report a patient with life‐threatening disease treated successfully with combination chemotherapy consisting of methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP‐B) who achieved complete remission and remains disease‐free over 3 years from diagnosis. Justification for an aggressive therapeutic approach to this disease is presented.