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Primary central nervous system lymphoma as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia
Author(s) -
O'neill Brin P.,
Habermann Thomas M.,
Banks Peter M.,
O'Fallon Judith R.,
Earle John D.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890915)64:6<1296::aid-cncr2820640621>3.0.co;2-e
Subject(s) - medicine , chronic lymphocytic leukemia , lymphoma , pathology , differential diagnosis , central nervous system , leukemia , primary central nervous system lymphoma , parenchyma , immunology
Primary parenchymal central nervous system (CNS) non‐Hodgkin's lymphoma subsequently developed in two patients with chronic lymphocytic leukemia (CLL). These two patients represent what we believe to be the first examples of Richter's syndrome due to primary brain lymphoma. Neither evidence for systemic lymphoma nor of progression of the leukemia was found. We believe that the description of these two cases expands the clinical spectrum in which Richter's syndrome may occur. In patients with CLL, careful attention must be given to neurologic symptoms, particularly those that develop abruptly. Primary CNS lymphoma must enter into the differential diagnosis when a cerebral mass lesion is found in such patients by the appropriate neuro‐imaging.