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Beta‐glucuronidase activity in prostatic carcinoma and benign prostatic hyperplasia
Author(s) -
Pearson Jeffrey P.,
Pretlow Theresa P.,
Bradley Edwin L.,
McGinnis Michael C.,
Pretlow Thomas G.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890815)64:4<911::aid-cncr2820640425>3.0.co;2-b
Subject(s) - hyperplasia , medicine , carcinoma , prostatic diseases , prostate , glucuronidase , beta glucuronidase , prostatic disease , pathology , adenoma , enzyme , cancer , chemistry , biochemistry , gene expression , gene
Beta‐glucuronidase activity was extracted from prostatic carcinomas and hyperplastic prostates. It was 3.6‐fold higher ( P < 0.0001) in prostatic carcinoma than in prostatic hyperplasia. Analysis for isoenzymes of prostatic beta‐glucuronidase by disc‐gel electrophoresis in nondenaturing polyacrylamide gels demonstrated only one form of the enzyme. Histochemically, enzymatic activity was observed almost entirely in epithelial cells in both prostatic carcinoma and benign prostatic hyperplasia.