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Prevention of prostate cancer and liver tumors in L‐W rats by moderate dietary restriction
Author(s) -
Pollard Morris,
Luckert Phyllis H.,
Snyder David
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890801)64:3<686::aid-cncr2820640320>3.0.co;2-q
Subject(s) - medicine , hyperplasia , incidence (geometry) , prostate , stromal cell , prostate cancer , lesion , endocrinology , physiology , cancer , medullary cavity , pathology , physics , optics
Aging conventional (CV) and germfree Lobund‐Wistar (L‐W) rats developed spontaneous tumors, predominantly in the prostate, liver, and adrenal glands. In CV L‐W rats a 30% reduction of daily intake (natural ingredient diet L‐485) had the following effects: (1) reduction of the incidence of metastatic prostate adenocarcinomas (PA) from 25.7% to 6.3% and extension of the average latent periods from 26.6 to 36.7 months; and (2) reduction of the incidence of hepatomas from 59% to 26% and extension of the average latent periods from 31.3 to 34 months. Adrenal medullary tumors developed in approximately 60% of rats older than 19 months, regardless of dietary intake and microbial status. Stromal hyperplasia developed among 36 of 78 (46%) rats older than age 30 months. Rats with PA were free of stromal hyperplasia, and the reverse was also true. Germfree L‐W rats developed all of the above tumors, but the diet‐related differences were not as significant as those among the conventional counterpart rats. The incidence of prostatitis was reduced from 22% to 6% among the diet‐restricted rats, but this lesion did not develop among the germfree rats.