Premium
Flow cytometric analysis DNA content in esophageal carcinoma. Correlation with histologic and clinical features
Author(s) -
JinMing Yu,
LiHua Yang,
YanTiao Chen,
Xiao Li,
WeiXia Zhong,
JiuCheng Chen,
GueDong Tian
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890701)64:1<80::aid-cncr2820640114>3.0.co;2-y
Subject(s) - pathology , nuclear dna , dna , carcinoma , medicine , lymph node , flow cytometry , lymph node metastasis , metastasis , biology , cancer , immunology , genetics , gene , mitochondrial dna
Cell nuclear DNA content was determined by flow cytometric analysis in 36 patients with esophageal carcinoma. Aneuploid DNA content was observed in 25 cases (69.4%). The relationships among DNA content, histopathologic features, and clinical characteristics were investigated. The patients with aneuploid DNA content had a high frequency of local lymph node metastasis, invasion to surrounding tissues, poor histologic differentiation, and advanced tumor stages as compared with those patients with diploid DNA content. In contrast to this, there was no correlation in patients' sex, age, and the sites of the disease.