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Precursor T‐cell lymphoma associated with human immunodeficiency virus type 1 (HIV‐1) infection. First reported case
Author(s) -
Ruff Paul,
Bagg Adam,
Papadopoulos Kyriakos
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890701)64:1<39::aid-cncr2820640108>3.0.co;2-1
Subject(s) - medicine , human immunodeficiency virus (hiv) , lymphoma , virology , virus , immunodeficiency , immunology , immune system
The majority of lymphomas that develop in human immunodeficiency virus type 1 (HIV‐1) positive patients have a B‐cell phenotype, with few reported cases of T‐cell lymphoma. Within the latter group, those that have been comprehensively phenotyped had a mature helper T‐cell phenotype (CD4+). We report, for the first time, an HIV‐1 positive patient with a precursor T‐cell lymphoma (CD7+, CD1‐, CD3‐, CD4‐, and CD8‐). T‐cell receptor beta and gamma genes were in the germline configuration and integration of HIV‐1 DNA could not be detected in the lymphoma cell genome.