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Hyperfractionation decreases the deleterious effects of conventional radiation fractionation on vertebral. Growth in animals
Author(s) -
Hartsell William F.,
Hanson Wayne R.,
Conterato Dean J.,
Hendrickson Frank R.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890615)63:12<2452::aid-cncr2820631215>3.0.co;2-3
Subject(s) - medicine , hyperfractionation , weanling , nuclear medicine , dose fractionation , vertebral column , radiation therapy , bone growth , skull , surgery
Craniospinal axis irradiation in the treatment of pediatric tumors is associated with serious long‐term sequelae including decreased bone growth (short sitting stature). In this study, an animal model was used to determine the effects of smaller incremental doses of radiation on bone growth. Sprague‐Dawley weanling rats were given 25 Gy to the spine in 8 to 9 days, with fraction sizes ranging from 1.0 to 1.8 Gy. The animals receiving smaller doses per fraction (1.0 or 1.25 Gy) showed significantly more growth of the vertebral bodies in the treated fields than animals given larger incremental doses (1.5 or 1.8 Gy). These findings indicate a protective effect on bone growth for hyperfractionated irradiation of vertebral bodies.