Premium
Intraperitoneal P‐32 after negative second‐look laparotomy in ovarian carcinoma
Author(s) -
Spencer T. Rhett,
Marks Richard D.,
Fenn Jimmy O.,
Jenrette Joseph M.,
Lutz Myrton H.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890615)63:12<2434::aid-cncr2820631211>3.0.co;2-b
Subject(s) - medicine , laparotomy , surgery , ovarian carcinoma , ovarian cancer , carcinoma , cancer
Thirty‐one patients underwent a negative second‐look laparotomy between 1976 and 1986. Fourteen patients received intraperitoneal chromic phosphate (P‐32) after a negative second‐look laparotomy. There has been no local recurrence (zero of 14) and no deaths attributable to recurrent disease. Local control and disease‐free survival are 100%, with a minimum follow‐up of 2 years and a mean follow‐up of 4 years. Seventeen patients received no further therapy because of patient refusal, poor diffusion, or other contraindications to P‐32 installation. Four of 17 patients undergoing negative second‐look procedures without the addition of P‐32 have subsequently recurred. This difference is highly suggestive (P =.076). There have been no major complications with the addition of P‐32. The use of intraperitoneal P‐32 after negative second‐look laparotomies on ovarian carcinoma is well tolerated and effective in preventing recurrence.