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Radical hysterectomy and tailored postoperative radiation therapy in the management of bulky stage 1B cervical cancer
Author(s) -
Rettenmaier Mark A.,
Casanova Diane M.,
Micha John P.,
Moran Mark F.,
Ramsanghani Nilam S.,
Syed Nissar A.,
Puthawala Ajmel,
Disaia Philip J.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890601)63:11<2220::aid-cncr2820631127>3.0.co;2-m
Subject(s) - medicine , radiation therapy , radical hysterectomy , stage (stratigraphy) , cervical cancer , brachytherapy , surgery , hysterectomy , paraaortic lymph nodes , lymph node , radical surgery , cancer , radiology , metastasis , paleontology , biology
Ninety‐two patients with Stage 1B cervical cancers having a diameter equal to or greater than 4.0 cm were treated with radical surgery. Thirty‐two patients received postoperative radiotherapy because of operative findings suggestive of high risk of pelvic recurrence. All 32 irradiated patients were treated with a standard pelvic field. Four patients also received paranortic radiotherapy, and ten received intravaginal brachytherapy. Postoperative complications were seen in five patients (two nonirradiated, three irradiated). Projected 5‐year survival is 79% (71% 5‐year survival in irradiated patients, and 83% 5‐year survival in nonirradiated patients). Preoperative evaluation of tumor volume was not found to reliably predict histologic high risk factors such as depth of stromal invasion, risk of lymph node metastases, or presence of extracervical/uterine involvement. A primary surgical approach in this group of patients with large‐diameter Stage IB cervical cancers allows definition of those patients who might benefit from a combined surgical and radiotherapeutic approach to treatment based on findings at operation.