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The effect of sex hormones and tamoxifen on the growth of human gastric and colorectal cancer cell lines
Author(s) -
Harrison J. D.,
Watson S.,
Morris D. L.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890601)63:11<2148::aid-cncr2820631113>3.0.co;2-c
Subject(s) - tamoxifen , medicine , endocrinology , dihydrotestosterone , agonist , cell culture , hormone , metabolite , cancer , estrogen , cell growth , androgen , cancer research , receptor , biology , breast cancer , genetics
The authors studied the effect of serial concentrations of estradiol, 4‐hydroxytamoxifen with estradiol, and 5‐dihydrotestosterone on cell lines derived from human gastric and colorectal cancers. Significant stimulation of the gastric and 2 colorectal cell lines occurred at physiologic concentrations of estradiol. Addition of the active metabolite of the estrogen‐receptor blocker/partial‐agonist 4‐hydroxytamoxifen had a stimulating effect on the growth rate of the gastric cell lines. The androgen, 5‐dihydrotestosterone, had a modest inhibitory effect on the two gastric cell lines and two of the colorectal cell lines, and a stimulating effect on two further cell lines.