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Cystosarcoma phyllodes. Effective therapy with cisplatin and etoposide chemotherapy
Author(s) -
Burton Gary V.,
Hart Lowell L.,
Leight George S.,
Iglehart James D.,
McCarty Kenneth S.,
Cox Edwin B.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890601)63:11<2088::aid-cncr2820631103>3.0.co;2-c
Subject(s) - medicine , radiation therapy , etoposide , chemotherapy , hormonal therapy , cisplatin , hormone therapy , oncology , hormone , hormone receptor , breast cancer , cancer
Cystosarcoma phyllodes is an unusual breast neoplasm that rarely metastasizes. Most series report chemotherapy, radiation, and hormonal therapy to be ineffective. Three patients were treated with cisplatin and etoposide combination chemotherapy with effective palliation in two patients. Radiation therapy was effective in controlling symptomatic metastasis in all three patients. Hormonal therapy was ineffective in two patients despite the presence of positive hormone receptors. Chemotherapy and radiotherapy may be more effective in the treatment of this tumor than has been reported, although there is no apparent role for hormonal therapy. Functional hormone receptors are probably not present.