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Four‐day continuous infusion of cisplatin and 5‐fluorouracil in head and neck cancer
Author(s) -
Bernal Amalia G.,
Cruz Juan J.,
Sánchez Pedro,
Muñoz Angel,
Nieto Adelaida,
Fonseca Emilio,
Calle Rodoil,
Luis Gómez J.
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890515)63:10<1927::aid-cncr2820631010>3.0.co;2-1
Subject(s) - medicine , fluorouracil , cisplatin , head and neck cancer , regimen , continuous infusion , head and neck , surgery , chemotherapy , complete response , cancer , oncology , anesthesia
A combination of cisplatin and 5‐fluorouracil, both administered 4 days continuously as infusion, was assessed in advanced head and neck cancer. Of the 37 patients studied, there were 15 complete and 17 partial responses (40.5% and 45.9%, repectively). Survival is 79.1% at 22 months. None of the patients in complete response has relapsed. In general toxic effects were moderate. Given as initial treatment, the regimen is effective and of considerable use in this type of patient.