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Prognostic significance of Ki‐67 reactivity in soft tissue sarcomas
Author(s) -
Ueda Takafumi,
Aozasa Katsuyuki,
Tsujimoto Masahiko,
Ohsawa Masahiko,
Uchida Atsumasa,
Aoki Yasuaki,
Ono Keiro,
Matsumoto Keishi
Publication year - 1989
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19890415)63:8<1607::aid-cncr2820630827>3.0.co;2-1
Subject(s) - medicine , ki 67 , immunohistochemistry , pathology , mitotic index , soft tissue , grading (engineering) , histology , mitosis , biology , ecology , microbiology and biotechnology
Proliferative activity of soft tissue sarcomas (STS) in 34 cases was estimated by immunohistochemical procedures (avidin‐biotin complex [ABC] method) with monoclonal antibody Ki‐67 which reacts with a nuclear antigen expressed in all phases of cell cycle except G 0 . In 20 of 34 cases (59%), varying numbers of Ki‐67‐positive tumor cells were detected with a range from 5 to 382 per 10 high power fields (HPF) (mean 57.2/10 HPF). Ki‐67 index (the number of Ki‐67‐positive tumor cells/10 HPF) positively correlated with mitotic count (r = 0.428, P < 0.02), cellularity (r = 0.447, P < 0.01), and histologic grade (r = 0.473, P < 0.01). The Ki‐67 low index group (less than 50/10 HPF) showed more favorable prognosis than the high index group (more than 50/10 HPF) (P < 0.005). Three cases with low mitotic count and unfavorable prognosis were proved to be the Ki‐67 high index group (142‐382/10 HPF). These results indicated that reactivity of tumor cells for Ki‐67 is a useful prognostic marker in the patients with STS, and might be used as one of the histologic factors for the grading of STS.